With NT/2K/XP you will encounter a permission issue. Regular users would not have rights to write to HKLM.
So why do you need to stuff RunOnce anyway? Like I said before, that is just for cases where HKCU is not available during logon. That should not be the case here, only on Wintendos. You should be able to do the IE settings directly from the logon script.
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Give a man a fish and he will be back for more. Slap him with a fish and he will go away forever.
