I don't suggest changing this setting. From experience, every version of Windows since this was introduced has gotten more and more reliant on that setting remaining on. I think starting with Win10, you couldn't run Edge, the calculator, or ANY other App (ie Store Apps).

However, If you have access to the GPOs, this setting could be changed by creating a registry setting and deploying it that way. Running an admin script would also allow you to do it as well. If users are admins of their pc I have also had luck bypassing the UAC by using elevate.exe. (Do a search on the board for it as we have discussed it in the past)