Try single (') outside and double (") inside.
shell '"C:\Program Files (x86)\CaafSi\PRATICHEPLUR\Pratiche2\Pratiche2_11.exe" "C:\Program Files (x86)\\CaafSi\Custom\CAAF11.INI"'
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Give a man a fish and he will be back for more. Slap him with a fish and he will go away forever.