Lots of mistakes...
Assuming that this is supposed to be a UNC path, you are missing the hacks.
$PatchLoc="\\SYDFILESVR\MIS\SUPP\"

You should pull this path from the registry with ReadValue().
$ProfileLoc=%USERPROFILE%

You dan't say waht is a file or a folder. Folders should have a trailing hack.
Copy $PatchLoc + "PSL\Helpdesk DB\" $ProfileLoc + "\Desktop\"
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