There certainly can be degradation if a computer is not rebooted often. Memory can and will fragment even if it is not consumed by a leaky app.
We encourage users to do a restart every night. That way we can perform maintenance without concern that they may have apps open with unsaved work. Very few of course, comply so we are frequently calling them in from home when we need to take downtime.
Newer computers we can power up with WOL provided they don't turn off their powerbars.
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Give a man a fish and he will be back for more. Slap him with a fish and he will go away forever.
